Lionel M Chow, MD

Dr. Lionel Chow is a pediatric hematologist and oncologist with an expertise in childhood brain cancer. He works with a multidisciplinary team of experts to provide patients and families with the best care and treatment available for brain tumors that also meets the unique medical and psychological needs of each patient. He is a cancer researcher whose work has focused on finding better treatments for aggressive brain tumors in children and adults. He has published over 40 research papers in internationally recognized journals and presented his research at international conferences. Dr. Chow received his medical training and research doctorate at McGill University in Montreal, Canada. He completed his pediatric residency and hematology/oncology training at The Hospital for Sick Children in Toronto, Canada where he was a chief fellow. He then moved to St. Jude Children’s Research Hospital in Memphis, Tennessee where he developed an interest in brain tumor research in the lab. He also completed clinical training in pediatric neuro-oncology at St. Jude. He moved to Cincinnati Children’s Hospital Medical Center where he established his own brain tumor laboratory and was a member of the brain tumor program. Dr. Chow joined the hematology/oncology program at Dayton Children’s hospital in 2018 and provides a team-based family-centered approach to the care of brain tumor patients. He is also continuing his research on childhood brain tumors with a goal of developing better treatment options for patients with aggressive forms of this disease. Dr. Chow serves as the chair of the Medical Advisory Committee for Joshua’s Wish, a private foundation that raises money to support families and research on diffuse intrinsic pontine glioma. He also speaks at several fundraising events in southwestern Ohio. He was awarded a Jean François St-Denis Fellowship in Cancer Research by the Canadian Institutes of Health Research (2005) and was named a St. Baldrick’s Foundation Scholar (2011) as well as a Distinguished Scientist by the Sontag Foundation (2011).

awards and honors:
Dayton Magazine - Dayton Best Docs 2023
Fellow of the Royal College of Physicians of Canada

organizations:
American Association for the Advancement of Science
American Association of Cancer Research
American Society of Clinical Oncology
Society for Neuro-Oncology
Children's Oncology Group

publications and presentations:
Chow, L.M.L., M.J.H. Ratcliffe and A. Veillette. (1992) tkl is the avian homolog of the mammalian lck tyrosine protein kinase gene. Mol. Cell. Biol. 12:1226-1233. PMID: 1545804; PMCID: PMC369554
Davidson, D., L.M.L. Chow, M. Fournel and A. Veillette. (1992) Differential regulation of T cell antigen responsiveness by isoforms of the src-related tyrosine protein kinase p59fyn. J. Exp. Med. 175:1483-1492. PMID: 1375262; PMCID: PMC2119231.
Chow, L.M.L., M. Fournel, D. Davidson and A. Veillette. (1993) Negative regulation of T-cell receptor signalling by tyrosine protein kinase p50csk. Nature 365:156-160. PMID: 8371758.
Gervais, F.G., L.M.L. Chow, J.M. Lee, P.E. Branton and A. Veillette. (1993) The SH2 domain is required for stable phosphorylation of p56lck at tyrosine 505, the negative regulatory site. Mol. Cell. Biol. 13:7112-7121. PubMed PMID: 8413300; PMCID: PMC364772.
Chow, L.M.L., C. Jarvis, Q. Hu, S.H. Nye, F.G. Gervais, A. Veillette and L.A. Matis. (1994) Ntk: A Csk-related protein-tyrosine kinase expressed in brain and T lymphocytes. Proc. Natl. Acad. Sci. U.S.A. 91:4975-4979. PubMed PMID: 8197166; PMCID: PMC43912.
Chow, L.M.L., D. Davidson, M. Fournel, P. Gosselin, S. Lemieux, M.S. Lyu, C.A. Kozak, L.A. Matis and A. Veillette. (1994) Two distinct protein isoforms are encoded by ntk, a csk-related tyrosine protein kinase gene. Oncogene 9:3437-3448. PMID: 7970703.
Chow, L.M.L., and A. Veillette. (1995) The Src and Csk families of tyrosine protein kinases in hemopoietic cells. Semin. Immunol. 7:207-226. PMID: 8520026.
Cloutier, J.-F., L.M.L. Chow and A. Veillette. (1995) Requirement of the SH3 and SH2 domains for the inhibitory function of tyrosine protein kinase p50csk in T-lymphocytes. Mol. Cell. Biol. 15:5937-5944. PMID: 7565746; PMCID: PMC230845.
Latour, S., L.M.L. Chow and A. Veillette. (1996) Differential intrinsic activity of Syk and Zap-70 protein-tyrosine kinases. J. Biol. Chem. 271:22782-22790. PMID: 8798454.
Davidson, D., L.M.L. Chow and A. Veillette. (1997) Chk, a Csk family tyrosine protein kinase, exhibits Csk-like activity in fibroblasts, but not in an antigen-specific T-cell line. J. Biol. Chem. 272:1355-1362. PMID: 8995444.
Treacy, E.P., B.R. Akerman, L.M.L. Chow, R. Youil, C. Bibeau, J. Lin, A.G. Bruce, M. Knight, D.M. Danks, J.R. Cashman and S.M. Forrest. (1998) Mutations of the flavin-containing monooxygenase gene (FMO3) cause trimethyaminuria, a defect in detoxification. Hum. Mol. Genet. 7:839-845. PMID: 9536088
Akerman, B.R., S.M. Forrest, L.M.L. Chow, R. Youil, M. Knight and E.P. Treacy. (1999) Two novel mutations of the FMO3 gene in a proband with trimethylaminuria. Hum. Mutat. 13:376-379. PMID: 10338091
Akerman, B.R., H. Lemass, L.M.L. Chow, D.M. Lambert, C. Greenberg, C. Bibeau, O.A. Mamer and E.P. Treacy. (1999) Trimethyaminuria is caused by mutations of the FMO3 gene in a North American cohort. Mol. Genet. Metab. 68:24-31. PMID: 10479479
Chow, L.M.L., J.N. Friedman, C. MacArthur, R. Restrepo, M. Temple, P.G. Chait and B. Connolly. (2003) Peripherally inserted central catheter (PICC) fracture and embolization in the pediatric population. J. Pediatr. 142:141-144. PMID: 12584534
Chow, L.M.L., M. Capra, Z. Levichek, G. Koren and R.M. Grant. (2004) Toxic ingestion of 6-mercaptopurine by young siblings of pediatric oncology patients. J. Pediatr. 144:669-671. PMID: 15127011
Chow, L.M.L. and S.J. Baker. (2006) PTEN function in normal and neoplastic growth. Cancer Lett. 241:184-196. PMID: 16412571
Chow, L.M.L., Y. Tian, T. Weber, M. Corbett, J. Zuo and S.J. Baker. (2006) Inducible Cre recombinase activity in mouse cerebellar granule cell precursors and inner ear hair cells. Dev. Dyn. 235:2991-2998. PMID: 16958097.
Chow, L.M.L., P.C. Nathan, D.C. Hodgson, D. Jenkin, S. Weitzman, R.M. Grant, D. Manson, A. Bross, J.J. Doyle, C. Danjoux and M. Greenberg. (2006) Survival and late effects in children with Hodgkin’s lymphoma treated with MOPP/ABV and low-dose, extended-field irradiation. J. Clin. Oncol. 24:5735-5741. PMID: 17179107
Weber, T., M.K. Corbett, L.M.L. Chow, M.B. Valentine, S.J. Baker and J. Zuo. (2008) Rapid cell-cycle reentry and cell death after acute inactivation of the retinoblastoma gene product in postnatal cochlear hair cells. Proc. Natl. Acad. Sci. U.S.A. (2008) Jan 15;105(2):781-5. PMID: 18178626; PMCID: PMC2206613
Chow, L.M.L., J. Zhang and S.J. Baker. (2008) Inducible Cre recombinase activity in mouse mature astrocytes and adult neural precursor cells. Transgenic Res. 17:919-928. PMID: 18483774; PMCID: PMC2522290.
Cicero, S.A., D. Johnson, S. Reyntjens, S. Frase, S. Connell, L.M.L. Chow, S.J. Baker, B.P. Sorrentino and M.A. Dyer (2009) Cells previously identified as retinal stem cells are pigmented ciliary epithelial cells. Proc. Natl. Acad. Sci. U.S.A. 106:6685-6690. PMID: 19346468; PMCID: PMC2672506.
Lavado, A., O. Lagutin, L.M.L. Chow, S.J. Baker and G. Oliver. (2010) Prox1 is required for granule cell maturation and intermediate progenitor maintenance during brain neurogenesis. PLoS Biol. 8:e1000460. PMID: 20808958; PMCID: PMC2923090
Chow, L.M.L., R. Endersby, X. Zhu, S. Rankin, C. Qu, J. Zhang, A. Broniscer, D.W. Ellison and S. J. Baker. (2011) Cooperativity within and among Pten, p53 and Rb pathways induces high-grade astrocytoma in adult brain. Cancer Cell 19:305-316. PMID: 21397855; PMCID: PMC3060664
Dorris, K., M. Fouladi, S.M. Davies, J. Perentesis, J.M. Lawrence, L.M.L. Chow, A. Assa’ad, B. Uygungil and S. Jodele. (2011) Severe delayed-type allergic reaction to thiol-based chemoprotective agents mesna and amifostine in a child with a supratentorial primitive neuroectodermal tumor. J. Pediatr. Hematol. Oncol. 33:e250-252. PMID: 21646919
Elmeliegy, M.A., A.M. Carcaboso, L.M.L. Chow, Z.M. Zhang, C. Calabrese, S.L. Throm, F. Wang, S.J. Baker and C.F. Stewart. (2011) Magnetic resonance imaging (MRI)-guided microdialysis cannula implantation in a spontaneous high-grade glioma murine model. J. Pharm. Sci. 100:4210-4214. PMID: 21837651; PMCID: PMC3750095
Chow, L.M.L. and S.J. Baker. (2012) Capturing the molecular and biological diversity of high-grade astrocytoma in genetically engineered mouse models. Oncotarget 3:67-77. PMID: 22287481; PMCID: PMC3292893
Zhu, G., L.M.L. Chow, I.T. Bayazitov, Y. Tong, R.J. Gilbertson, S.S. Zakharenko, D.J. Solecki and S.J. Baker. (2012) Pten deletion causes mTorc1-dependent ectopic neuroblast differentiation without causing uniform migration defects. Development 139:3422-3431. PMID: 22874917; PMCID: PMC3424045
Hummel, T.R., L.M.L. Chow, M. Fouladi and D. Franz. (2013) Pharmacotherapeutic management of pediatric astrocytomas: current and upcoming strategies. Pediatric Drugs 15:29-42. PMID: 23329387
Joshi, K., Y. Banasavadi-Siddegowda, X. Mo, S.H. Kim, P. Mao, C. Kig, D. Nardini, R.W. Sobol, L.M.L. Chow, H.I. Kornblum, R. Waclaw, M. Beullens and I. Nakano. (2013) MELK-dependent FOXM1 phosphorylation is essential for proliferation of glioma stem cells. Stem Cells 31:1051-1063. PMID: 23404835; PMCID: PMC3744761.
Zhong, Y., Y.-W. Wan, K. Pang, L.M.L. Chow and Z. Liu. (2013) Digital sorting of complex tissues for cell type-specific gene expression profiles. BMC Bioinformatics 14:89. PMID: 23497278; PMCID: PMC3626856.
Rafalski, V.A., P.P. Ho, J.O. Brett, D. Ucar, J.C. Dugas, E.A. Pollina, L.M.L. Chow, A. Ibrahim, S.J. Baker, B.A. Barres, L. Steinman and A. Brunet. (2013) Expansion of oligodendrocyte progenitor cells upon SIRT1 inactivation in the adult brain. Nature Cell Biol. 15:614-624. PMID: 23644469; PMCID: PMC4026158
Wojton, J., Z. Chu, H. Mathsyaraja, W.H. Meisen, N. Denton, C.-H. Kwon, L.M.L. Chow, M. Palascak, R. Franco, T. Bourdeau, S. Thornton, M.C. Ostrowski, B. Kaur and X. Qi. (2013) Systemic delivery of SapC-DOPS has antiangiogenic and antitumor effects against glioblastoma. Mol. Ther. 21:1517-1525. PMID: 23732993; PMCID: PMC3734660.
Liu, X., R.R. Chhipa, S. Pooya, M. Wortman, S. Yachyshin, L.M.L. Chow, A. Kumar, X. Zhou, Y. Sun, B. Quinn, C. McPherson, R.E. Warnick, A. Kendler, S. Giri, J. Poels, K. Norga, B. Viollet, G.A. Grabowski and B Dasgupta. (2014) Discrete mechanism of mTOR and cell cycle regulation by AMPK agonists independent of AMPK. Proc. Natl. Acad. Sci. U.S.A. 111:E435-444. PMID: 24474794; PMCID: PMC3910576
Salloum, R., M. DeWire, A. Lane, S. Goldman, T. Hummel, L. Chow, L. Miles, M. Sutton, C. Stevenson, M. Fouladi and J. Leach. (2015) Patterns of progression in pediatric patients with high-grade glioma or diffuse intrinsic pontine glioma treated with bevacizumab-based therapy at diagnosis. J. Neurooncol. 121:591-598. PMID: 25433556
Gass, D., M. DeWire, L. Chow, S.R. Rose, S. Lawson, C. Stevenson, A.L. Pai, B. Jones, M. Sutton, A. Lane, D. Pruitt, M. Fouladi and T.R. Hummel. (2015) Pediatric tectal plate gliomas: a review of clinical outcomes, endocrinopathies, and neuropsychological sequelae. J. Neurooncol. 122:169-177. PMID: 25582835.
Dave, N., L.M.L. Chow, G.A. Gudelsky, K. LaSance, X. Qi and P.B. Desai. (2015) Pre-clinical pharmacological evaluation of letrozole as a novel treatment for gliomas. Mol. Cancer Ther. 14:857-864. PMID: 25695958; PMCID: PMC4631403
Hummel, T.R., R. Salloum, R. Drissi, S. Kumar, M. Sobo, S. Goldman, A. Pai, J. Leach, A. Lane, D. Pruitt, M. Sutton, L.M.L. Chow, L. Grimme, R. Doughman, L. Backus, L. Miles, C. Stevenson, M. Fouladi and M. DeWire. (2015) A pilot study of bevacizumab-based therapy in patients with newly diagnosed high-grade gliomas and diffuse intrinsic pontine gliomas. J. Neurooncol. 127:53-61. PMID: 26626490
Hoffman, L.M., M. DeWire, S. Ryall, P. Buczkowicz, J. Leach, L. Miles, A. Ramani, M. Brudno, S.S. Kumar, R. Drissi, P. Dexheimer, R. Salloum, L. Chow, T. Hummel, C. Stevenson, Q.R. Lu, B. Jones, D. Witte, B. Aronow, C.E. Hawkins and M. Fouladi. (2016) Spatial genomic heterogeneity in diffuse intrinsic pontine and midline high-grade glioma: implications for diagnostic biopsy and targeted therapeutics. Acta Neuropathol. Commun. 4:1. PMID: 26727948; PMCID: PMC4700584
Steed, T.C., J.M. Treiber, K. Patel, V. Ramakrishnan, A. Merk, A.R. Smith, B.S. Carter, A.M. Dale, L.M.L. Chow and C.C. Chen. (2016) Differential localization of glioblastoma subtype: implications on glioblastoma pathogenesis. Oncotarget 7:24899-24907. PMID: 27056901; PMCID: PMC5041878
Zhu, G., S.L. Rankin, J.D. Larson, X. Zhu, L.M.L. Chow, C. Qu, J. Zhang, D.W. Ellison and S.J. Baker. (2017) PTEN signaling in the postnatal perivascular progenitor niche drives medulloblastoma formation. Cancer Res. 77:123-133. PMID: 27815386; PMCID: PMC5214974
Anderson, J., R. Muraleedharan, N. Oatman, A. Klotter, S. Sengupta, R.R. Waclaw, J. Wu, R. Drissi, L. Miles, E.H. Raabe, M. Weirauch, M. Fouladi, L.M.L. Chow, L. Hoffman, M. DeWire and B. Dasgupta. (2017) The transcription factor Olig2 is important for the biology of diffuse intrinsic pontine gliomas. Neuro-Oncol. 19:1068-1078. PMID: 28339768; PMCID: PMC5570182
Salloum, R., M.K. McConechy, L.G. Mikael, C. Fuller, R. Drissi, M. DeWire, H. Nikbakht, N. De Jay, X. Yang, D. Boue, L.M.L. Chow, J.L. Finlay, T. Gayden, J. Karamchandani, T.R. Hummel, R. Olshefski, D.S. Osorio, C. Stevenson, C.L. Kleinman, J. Majewski, M. Fouladi and N. Jabado. (2017) Characterizing temporal genomic heterogeneity in pediatric high-grade gliomas. Acta Neuropathol. Commun. 5:78. PMID: 29084603; PMCID: PMC5663045
Sengupta, S., M. Sobo, K. Lee, S.S. Kumar, A.R. White, I. Mender, C. Fuller, L.M.L. Chow, M. Fouladi, J.W. Shay and R. Drissi. (2018) Induced telomere damage to treat telomerase expressing therapy-resistant pediatric brain tumors. Mol. Cancer Ther. 17:1504-1514. PMID: 29654065
Chadwick, M.L., A. Lane, D. Thomas, A.R. Smith, A.R. White, D. Davidson, Y. Feng, E. Boscolo, Y. Zheng, D.M. Adams, A. Gupta, A. Veillette and L.M.L. Chow. (2018) Combined mTOR and MEK inhibition is an effective therapy in a novel mouse model for angiosarcoma. Oncotarget 9:24750-24765. PMID: 29872503; PMCID: PMC5973867
Chhipa, R.R., Q. Fan, J. Anderson, R. Muraleedharan, Y. Huang, G. Ciraolo, X. Chen, R. Waclaw, L.M.L. Chow, Z. Khuchua, M. Kofron, M.T. Weirauch, A. Kendler, C. McPherson, N. Ratner, I. Nakano, N. Dasgupta, K. Komurov and B. Dasgupta. (2018) AMP kinase promotes glioblastoma bioenergetics and tumor growth. Nature Cell Biol. 20:823-835. PMID: 29915361